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Heart doctors urge caution with drug stents - Heart Health - MSNBC.com
Source: MSNBC NEWS Author: MSNBC NEWS Published date: 2007-01-12  

Heart doctors urge caution with drug stents

Group supports continued use of coated devices, with conditions

CHICAGO - A group representing 3,700 cardiologists around the world Thursday warned physicians to be careful when recommending drug-eluting stents to treat diseased arteries.

Amid a flurry of controversy over the popular heart devices, the Society for Cardiovascular Angiography and Interventions said it supports continued use, but stressed the importance of careful patient selection, meticulous implantation and consistent use of blood thinners to prevent blood clots.

Stents, tiny wire mesh tubular devices, are inserted into diseased arteries after the blood vessels have been unclogged. The drug coating on the metal keeps vessels from reclogging. Drug-eluting stents quickly supplanted the bare metal variety when the drug-eluting versions were launched three years ago.

Recently however, doctors have become concerned about a small, but serious risk for deadly blood clots that can form long after the drug-eluting devices are implanted.

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The Food and Drug Administration is reviewing the matter after an advisory panel debated it last month, concluding that the benefits outweigh the risks when placed in appropriate patients. The panel called for more research.

Dr. Kirk Garratt, clinical director of Interventional Cardiovascular Research at Lenox Hill Hospital in New York, echoed the view of the FDA panel, saying more data was needed to answer important questions, like what about the device causes clotting.

"We don't understand the mechanism of the clots in this instance. Is it the polymer on the stent? That's probably the leading contender, but we don't know," he said.

Garratt is an advisor to Boston Scientific Corp. , one of just two manufacturers approved to sell the devices in the United States. Johnson & Johnson is the other company approved to sell drug-eluting stents on the U.S. market.

Abbott Laboratories , Medtronic Inc. and Conor MedSystems?which agreed to be acquired by J&J, sell their own versions overseas, and are poised to launch in the United States over the next couple of years.

Copyright 2007 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content is expressly prohibited without the prior written consent of Reuters.

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